Please use this identifier to cite or link to this item:
http://hdl.handle.net/10773/27706
Title: | Distribution of distances between symmetric words in the human genome: analysis of regular peaks |
Author: | Bastos, Carlos A. C. Afreixo, Vera Rodrigues, João M. O. S. Pinho, Armando J. Silva, Raquel M. |
Keywords: | Cruciform Distance distribution Genomic word Reversed complements Inverted repeats Regular peaks |
Issue Date: | 1-Sep-2019 |
Publisher: | Springer Verlag |
Abstract: | Finding DNA sites with high potential for the formation of hairpin/cruciform structures is an important task. Previous works studied the distances between adjacent reversed complement words (symmetric word pairs) and also for non-adjacent words. It was observed that for some words a few distances were favoured (peaks) and that in some distributions there was strong peak regularity. The present work extends previous studies, by improving the detection and characterization of peak regularities in the symmetric word pairs distance distributions of the human genome. This work also analyzes the location of the sequences that originate the observed strong peak periodicity in the distance distribution. The results obtained in this work may indicate genomic sites with potential for the formation of hairpin/cruciform structures. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/27706 |
DOI: | 10.1007/s12539-019-00326-x |
ISSN: | 1913-2751 |
Appears in Collections: | CIDMA - Artigos DETI - Artigos IBIMED - Artigos DMat - Artigos IEETA - Artigos DCM - Artigos PSG - Artigos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Bastos2019a.pdf | 1.85 MB | Adobe PDF |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.