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Title: An integrative approach for codon repeats evolutionary analyses
Author: Lousado, José Paulo
Oliveira, José Luis
Moura, Gabriela
Santos, Manuel A. S.
Keywords: Codon repeats
Evolutionary analyses
Orthologous genes
Gene comparison
Tandem repeats
Data integration
Web services
Issue Date: 2012
Publisher: Inderscience
Abstract: The relationship between genome characteristics and several human diseases has been a central research goal in genomics. Many studies have shown that specific gene patterns, such as amino acid repetitions, are associated with human diseases. However, several open questions still remain, such as, how these tandem repeats appeared in the evolutionary path or how they have evolved in orthologous genes of related organisms. In this paper, we present a computational solution that facilitates comparative studies of orthologous genes from various organisms. The application uses various web services to gather gene sequence information, local algorithms for tandem repeats identification and similarity measures for gene clustering.
Peer review: yes
DOI: 10.1504/ijdmb.2012.049294
ISSN: 1748-5673
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DETI - Artigos
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