Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10773/27447
Título: | Impact of tRNA modifications and tRNA-modifying enzymes on proteostasis and human disease |
Autor: | Pereira, Marisa Francisco, Stephany Varanda, Ana Sofia Santos, Mafalda Santos, Manuel A. S. Soares, Ana Raquel |
Palavras-chave: | Transfer RNA tRNA modifications tRNA-modifying enzymes Proteostasis Conformational disorders Translation Protein aggregation Metabolic diseases Nervous system diseases Nucleic acid conformation tRNA methyltransferases Protein biosynthesis RNA processing, post-transcriptional |
Data: | Dez-2018 |
Editora: | MDPI |
Resumo: | Transfer RNAs (tRNAs) are key players of protein synthesis, as they decode the genetic information organized in mRNA codons, translating them into the code of 20 amino acids. To be fully active, tRNAs undergo extensive post-transcriptional modifications, catalyzed by different tRNA-modifying enzymes. Lack of these modifications increases the level of missense errors and affects codon decoding rate, contributing to protein aggregation with deleterious consequences to the cell. Recent works show that tRNA hypomodification and tRNA-modifying-enzyme deregulation occur in several diseases where proteostasis is affected, namely, neurodegenerative and metabolic diseases. In this review, we discuss the recent findings that correlate aberrant tRNA modification with proteostasis imbalances, in particular in neurological and metabolic disorders, and highlight the association between tRNAs, their modifying enzymes, translational decoding, and disease onset. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/27447 |
DOI: | 10.3390/ijms19123738 |
ISSN: | 1661-6596 |
Aparece nas coleções: | IBIMED - Artigos DCM - Artigos |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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ijms-19-03738.pdf | 1.71 MB | Adobe PDF | Ver/Abrir |
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