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Title: At the crossway of ER-stress and proinflammatory responses
Author: Reverendo, Marisa
Mendes, Andreia
Argüello, Rafael J.
Gatti, Evelina
Pierre, Philippe
Keywords: Dendritic cells
Endoplasmic reticulum
Innate immunity
Unfolded protein response
Issue Date: Jan-2019
Publisher: Wiley
Abstract: Immune cells detect specific microbes or damage to tissue integrity in order to initiate efficient immune responses. Abnormal accumulation of proteins in the endoplasmic reticulum (ER) can be seen as a sign of cellular malfunction and stress that triggers a collection of conserved emergency rescue programs. These different signaling cascades, which favor ER proteostasis and promote cell survival, are collectively known as the unfolded protein response (UPR). In recent years, a synergy between the UPR and inflammatory cytokine production has been unraveled, with different branches of the UPR entering in a cross-talk with specialized microbe sensing pathways, which turns on or amplify inflammatory cytokines production. Complementary to this synergetic activity, UPR induction alone, can itself be seen as a danger signal, and triggers directly or indirectly inflammation in different cellular and pathological models, this independently of the presence of pathogens. Here, we discuss recent advances on the nature of these cross-talks and how innate immunity, metabolism dysregulation, and ER-signaling pathways intersect in specialized immune cells, such as dendritic cells (DCs), and contribute to the pathogenesis of inflammatory diseases.
Peer review: yes
DOI: 10.1111/febs.14391
ISSN: 1742-464X
Appears in Collections:IBIMED - Artigos
DCM - Artigos

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