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Title: Photodynamic inactivation of mammalian viruses and bacteriophages
Author: Costa, Liliana
Faustino, Maria Amparo F.
Neves, Maria Graça P. M. S.
Cunha, Ângela
Almeida, Adelaide
Keywords: Bacteriophages
Mammalian viruses
Photodynamic therapy
Viral photoinactivation process
Issue Date: 2012
Publisher: MDPI
Abstract: Photodynamic inactivation (PDI) has been used to inactivate microorganisms through the use of photosensitizers. The inactivation of mammalian viruses and bacteriophages by photosensitization has been applied with success since the first decades of the last century. Due to the fact that mammalian viruses are known to pose a threat to public health and that bacteriophages are frequently used as models of mammalian viruses, it is important to know and understand the mechanisms and photodynamic procedures involved in their photoinactivation. The aim of this review is to (i) summarize the main approaches developed until now for the photodynamic inactivation of bacteriophages and mammalian viruses and, (ii) discuss and compare the present state of the art of mammalian viruses PDI with phage photoinactivation, with special focus on the most relevant mechanisms, molecular targets and factors affecting the viral inactivation process.
Peer review: yes
DOI: 10.3390/v4071034
ISSN: 1999-4915
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