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http://hdl.handle.net/10773/26946
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Paredes, João A. | pt_PT |
dc.contributor.author | Carreto, Laura | pt_PT |
dc.contributor.author | Simões, João | pt_PT |
dc.contributor.author | Bezerra, Ana R. | pt_PT |
dc.contributor.author | Gomes, Ana C. | pt_PT |
dc.contributor.author | Santamaria, Rodrigo | pt_PT |
dc.contributor.author | Kapushesky, Misha | pt_PT |
dc.contributor.author | Moura, Gabriela R. | pt_PT |
dc.contributor.author | Santos, Manuel A. S. | pt_PT |
dc.date.accessioned | 2019-11-12T14:51:49Z | - |
dc.date.available | 2019-11-12T14:51:49Z | - |
dc.date.issued | 2012-06-20 | - |
dc.identifier.issn | 1741-7007 | pt_PT |
dc.identifier.uri | http://hdl.handle.net/10773/26946 | - |
dc.description.abstract | Organisms use highly accurate molecular processes to transcribe their genes and a variety of mRNA quality control and ribosome proofreading mechanisms to maintain intact the fidelity of genetic information flow. Despite this, low level gene translational errors induced by mutations and environmental factors cause neurodegeneration and premature death in mice and mitochondrial disorders in humans. Paradoxically, such errors can generate advantageous phenotypic diversity in fungi and bacteria through poorly understood molecular processes. | pt_PT |
dc.language.iso | eng | pt_PT |
dc.publisher | BMC | pt_PT |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/98850/PT | pt_PT |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/64745/PT | pt_PT |
dc.relation | SYBARIS/HEALTH-F3-2009242220 | pt_PT |
dc.rights | openAccess | pt_PT |
dc.subject | Yeast | pt_PT |
dc.subject | Mistranslation | pt_PT |
dc.subject | tRNA | pt_PT |
dc.subject | Protein synthesis | pt_PT |
dc.subject | mRNA profiling | pt_PT |
dc.subject | Stress | pt_PT |
dc.subject | Proteotoxic stress | pt_PT |
dc.subject | Protein misfolding | pt_PT |
dc.subject | Unfolded protein response | pt_PT |
dc.title | Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast | pt_PT |
dc.type | article | pt_PT |
dc.description.version | published | pt_PT |
dc.peerreviewed | yes | pt_PT |
degois.publication.firstPage | 1 - 55 | pt_PT |
degois.publication.lastPage | 19 -55 | pt_PT |
degois.publication.title | BMC Biology | pt_PT |
degois.publication.volume | 10 | pt_PT |
dc.identifier.doi | 10.1186/1741-7007-10-55 | pt_PT |
Appears in Collections: | CESAM - Artigos DBio - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Paredes et al. - 2012 - Low level genome mistranslations deregulate the tr.pdf | 2.79 MB | Adobe PDF | View/Open |
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