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Title: Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast
Author: Paredes, João A.
Carreto, Laura
Simões, João
Bezerra, Ana R.
Gomes, Ana C.
Santamaria, Rodrigo
Kapushesky, Misha
Moura, Gabriela R.
Santos, Manuel A. S.
Keywords: Yeast
Protein synthesis
mRNA profiling
Proteotoxic stress
Protein misfolding
Unfolded protein response
Issue Date: 20-Jun-2012
Publisher: BMC
Abstract: Organisms use highly accurate molecular processes to transcribe their genes and a variety of mRNA quality control and ribosome proofreading mechanisms to maintain intact the fidelity of genetic information flow. Despite this, low level gene translational errors induced by mutations and environmental factors cause neurodegeneration and premature death in mice and mitochondrial disorders in humans. Paradoxically, such errors can generate advantageous phenotypic diversity in fungi and bacteria through poorly understood molecular processes.
Peer review: yes
DOI: 10.1186/1741-7007-10-55
ISSN: 1741-7007
Appears in Collections:CESAM - Artigos
DBio - Artigos

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