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http://hdl.handle.net/10773/26471
Title: | Novel magnetic stimulation methodology for low-current implantable medical devices |
Author: | Bernardo, Rodrigo Rodrigues, André Santos, Marco P. Soares dos Carneiro, Pedro Lopes, António Amaral, João Sequeira Amaral, Vitor Sequeira Morais, Raul |
Keywords: | Medical device Biomagnetic device Implantable device Magnetic stimulation Magnetic field |
Issue Date: | 30-Aug-2019 |
Publisher: | Elsevier |
Abstract: | Recent studies highlight the ability of inductive architectures to deliver therapeutic magnetic stimuli to target tissues and to be embedded into small-scale intracorporeal medical devices. However, to date, current micro-scale biomagnetic devices require very high electric current excitations (usually exceeding 1 A) to ensure the delivery of efficient magnetic flux densities. This is a critical problem as advanced implantable devices demand self-powering, stand-alone and long-term operation. This work provides, for the first time, a novel small-scale magnetic stimulation system that requires up to 50-fold lower electric current excitations than required by relevant biomagnetic technology recently proposed. Computational models were developed to analyse the magnetic stimuli distributions and densities delivered to cellular tissues during in vitro experiments, such that the feasibility of this novel stimulator can be firstly evaluated on cell culture tests. The results demonstrate that this new stimulative technology is able to deliver osteogenic stimuli (0.1-7 mT range) by current excitations in the 0.06-4.3 mA range. Moreover, it allows coil designs with heights lower than 1 mm without significant loss of magnetic stimuli capability. Finally, suitable core diameters and stimulator-stimulator distances allow to define heterogeneity or quasi-homogeneity stimuli distributions. These results support the design of high-sophisticated biomagnetic devices for a wide range of therapeutic applications. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/26471 |
DOI: | 10.1016/j.medengphy.2019.07.015 |
ISSN: | 1350-4533 |
Appears in Collections: | TEMA - Artigos DFis - Artigos DEM - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Paper_Medical Engineering and Physics_2019.pdf | 250.98 kB | Adobe PDF | View/Open |
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