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Title: Novel magnetic stimulation methodology for low-current implantable medical devices
Author: Bernardo, Rodrigo
Rodrigues, André
Santos, Marco P. Soares dos
Carneiro, Pedro
Lopes, António
Amaral, João Sequeira
Amaral, Vitor Sequeira
Morais, Raul
Keywords: Medical device
Biomagnetic device
Implantable device
Magnetic stimulation
Magnetic field
Issue Date: 30-Aug-2019
Publisher: Elsevier
Abstract: Recent studies highlight the ability of inductive architectures to deliver therapeutic magnetic stimuli to target tissues and to be embedded into small-scale intracorporeal medical devices. However, to date, current micro-scale biomagnetic devices require very high electric current excitations (usually exceeding 1 A) to ensure the delivery of efficient magnetic flux densities. This is a critical problem as advanced implantable devices demand self-powering, stand-alone and long-term operation. This work provides, for the first time, a novel small-scale magnetic stimulation system that requires up to 50-fold lower electric current excitations than required by relevant biomagnetic technology recently proposed. Computational models were developed to analyse the magnetic stimuli distributions and densities delivered to cellular tissues during in vitro experiments, such that the feasibility of this novel stimulator can be firstly evaluated on cell culture tests. The results demonstrate that this new stimulative technology is able to deliver osteogenic stimuli (0.1-7 mT range) by current excitations in the 0.06-4.3 mA range. Moreover, it allows coil designs with heights lower than 1 mm without significant loss of magnetic stimuli capability. Finally, suitable core diameters and stimulator-stimulator distances allow to define heterogeneity or quasi-homogeneity stimuli distributions. These results support the design of high-sophisticated biomagnetic devices for a wide range of therapeutic applications.
Peer review: yes
DOI: 10.1016/j.medengphy.2019.07.015
ISSN: 1350-4533
Appears in Collections:TEMA - Artigos
DFis - Artigos
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