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Title: Reactive models for biological regulatory networks
Author: Figueiredo, Daniel
Barbosa, Luís Soares
Keywords: Biological regulatory networks
Switch graphs
Issue Date: 2019
Publisher: Springer
Abstract: A reactive model, as studied by D. Gabbay and his collaborators, can be regarded as a graph whose set of edges may be altered whenever one of them is crossed. In this paper we show how reactive models can describe biological regulatory networks and compare them to Boolean networks and piecewise-linear models, which are some of the most common kinds of models used nowadays. In particular, we show that, with respect to the identification of steady states, reactive Boolean networks lie between piecewise linear models and the usual, plain Boolean networks. We also show this ability is preserved by a suitable notion of bisimulation, and, therefore, by network minimisation.
Peer review: yes
DOI: 10.1007/978-3-030-19432-1
ISBN: 978-3-030-19431-4
Appears in Collections:CIDMA - Capítulo de livro
AGG - Capítulo de livro

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