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http://hdl.handle.net/10773/24721
Title: | T lymphocytes alterations are associated with oxidized LDL, troponin T, white blood cells and C-reactive protein during acute myocardial infarction |
Author: | Napoleão, Patrícia Selas, Mafalda Freixo, Cláudia Carmo, Miguel Mota Viegas-Crespo, Ana Maria Ferreira, Rui Cruz Pinheiro, Teresa |
Keywords: | Acute coronary syndromes C-reactive protein Cardiac troponin T Longitudinal study Oxidized LDL T lymphocytes |
Issue Date: | 2014 |
Publisher: | IOS Press |
Abstract: | BACKGROUND: Auto-immune responses are associated with oxidized LDL (ox-LDL) release, a key factor in plaque destabilization. Data on the relationship between ox-LDL and T lymphocytes in human populations remains scarce. T cells also react with other molecules from the lesion and/or damage the myocardium. OBJECTIVE: The objective of the present study was to examine the relationship between circulating T lymphocytes, ox-LDL, markers of myocardial necrosis (cTnT), myocardial dysfunction (N-terminal pro-brain natriuretic peptide – NT-proBNP) and inflammation (C-reactive protein – CRP) in the setting of acute myocardial infarction. METHODS: A longitudinal study of 55 patients with ST-elevation myocardial infarction (STEMI) were evaluated at three time points: admission, 2 and 40 days following admission, together with 30 patients with stable angina (SA) and 56 subjects without coronary artery disease serving as controls (CTR). RESULTS: STEMI patients had maximal ox-LDL values and minimal levels of CD3+ T lymphocytes at admission, which was normalized during the recovery period. The increasing trend of CD3+ T cells was positively associated with an ox-LDL decline over time. CRP and cTnT longitudinal variations were negatively associated with the CD3+ T-cell increasing trend. These associations were not found in SA patients or controls. CONCLUSIONS: The associations found between CD3+ T lymphocytes, ox-LDL and cTnT suggest a specificity of the immune response in AMI towards arterial and myocardial inflammation and remodelling. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/24721 |
DOI: | 10.3233/CH-121644 |
ISSN: | 1386-0291 |
Appears in Collections: | CESAM - Artigos DBio - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Napoleao et al. - 2013 - T lymphocytes alterations are associated with oxid.pdf | 229.41 kB | Adobe PDF |
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