Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10773/24506
Título: | Multiobjective optimization to a TB-HIV/AIDS coinfection optimal control problem |
Autor: | Denysiuk, Roman Silva, Cristiana J. Torres, Delfim F. M. |
Palavras-chave: | Tuberculosis · · HIV Epidemic model Treatment strategies Optimal control theory Multiobjective optimization |
Data: | Mai-2018 |
Editora: | American Institute of Mathematical Sciences |
Resumo: | We consider a recent coinfection model for Tuberculosis (TB), Human Immunodeficiency Virus (HIV) infection, and Acquired Immunodeficiency Syndrome (AIDS) proposed in Silva and Torres (Discr Contin Dyn Syst 35(9):4639–4663, 2015). We introduce and analyze a multiobjective formulation of an optimal control problem, where the two conflicting objectives are minimization of the number of HIV-infected individuals with AIDS clinical symptoms and coinfected with AIDS and active TB; and costs related to prevention and treatment of HIV and/or TB measures. The proposed approach eliminates some limitations of previous works. The results of the numerical study provide comprehensive insights about the optimal treatment policies and the population dynamics resulting from their implementation. Some nonintuitive conclusions are drawn. Overall, the simulation results demonstrate the usefulness and validity of the proposed approach. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/24506 |
DOI: | 10.1007/s40314-017-0438-9 |
ISSN: | 0101-8205 |
Versão do Editor: | http://dx.doi.org/10.1007/s40314-017-0438-9 |
Aparece nas coleções: | CIDMA - Artigos SCG - Artigos |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
[366]Denysiuk_Silva_Torres.pdf | 1.25 MB | Adobe PDF |
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.