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Title: Chromatographic response functions in 1D and 2D chromatography as tools for assessing chemical complexity
Author: Matos, João T. V.
Duarte, Regina M. B. O.
Duarte, Armando C.
Keywords: Chemical complexity
Chromatographic optimization
Chromatographic response function (CRF)
Complex system
Comprehensive two-dimensional chromatography
Non-target analysis
Objective function
One-dimensional liquid chromatography (ID LC)
Optimization strategy
Issue Date: 2013
Publisher: Elsevier
Abstract: The design of systems for an unattended chromatographic optimization, especially the development of chromatographic response functions (CRFs), was a topic of great interest and development in the 1980s and early 1990s. This article is a critical review of the utilization of CRFs in chromatographic optimization. We discuss the most relevant CRFs, for application in 1D and 2D chromatography in accordance with the complexity of the populations and the systems from which the samples come and the type of analytical strategy. We outline the major challenges ahead for these methods in assessing chemical complexity.
Peer review: yes
DOI: 10.1016/j.trac.2012.12.013
ISSN: 0165-9936
Appears in Collections:CESAM - Artigos
DQ - Artigos

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