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http://hdl.handle.net/10773/22833
Title: | Effect of lysozyme addition on the activity of phages against Vibrio parahaemolyticus |
Author: | Mateus, L. Costa, L. Silva, Y. J. Pereira, C. Almeida, A. |
Keywords: | Aquaculture Fish pathogenic bacteria Lysozyme Phage therapy |
Issue Date: | 2014 |
Publisher: | Elsevier |
Abstract: | Phage therapy gained increased attention as an alternative to antibiotics in order to control bacterial diseases and prevent the spreading of multidrug-resistant bacteria in aquaculture. In this study, the addition of a lytic enzyme (lysozyme) during phage therapy was evaluated for the first time to control Vibrio infection. Three phages of Vibrio parahaemolyticus (VP-1, VP-2 and VP-3) were used. The results indicate that the combination of lysozyme and phage showed better activity in comparison to the activity of the phage alone. VP-1 and VP-2 phages in the presence of lysozyme were more effective in reducing bacterial concentration (reductions of 4.0 log) than the VP-3 phage (which was the most efficient against Vibrio). The application of phages along with lysozyme can be a very useful strategy to eliminate or reduce fish pathogenic bacteria in aquaculture, namely when less effective phages are available. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/22833 |
DOI: | 10.1016/j.aquaculture.2014.04.037 |
ISSN: | 0044-8486 |
Appears in Collections: | CESAM - Artigos DBio - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Mateus et al. - 2014 - Effect of lysozyme addition on the activity of pha.pdf | 487.99 kB | Adobe PDF |
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