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|Title:||Effect of lysozyme addition on the activity of phages against Vibrio parahaemolyticus|
Silva, Y. J.
Fish pathogenic bacteria
|Abstract:||Phage therapy gained increased attention as an alternative to antibiotics in order to control bacterial diseases and prevent the spreading of multidrug-resistant bacteria in aquaculture. In this study, the addition of a lytic enzyme (lysozyme) during phage therapy was evaluated for the first time to control Vibrio infection. Three phages of Vibrio parahaemolyticus (VP-1, VP-2 and VP-3) were used. The results indicate that the combination of lysozyme and phage showed better activity in comparison to the activity of the phage alone. VP-1 and VP-2 phages in the presence of lysozyme were more effective in reducing bacterial concentration (reductions of 4.0 log) than the VP-3 phage (which was the most efficient against Vibrio). The application of phages along with lysozyme can be a very useful strategy to eliminate or reduce fish pathogenic bacteria in aquaculture, namely when less effective phages are available.|
|Appears in Collections:||CESAM - Artigos|
DBio - Artigos
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|Mateus et al. - 2014 - Effect of lysozyme addition on the activity of pha.pdf||487.99 kB||Adobe PDF|
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