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http://hdl.handle.net/10773/20595
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | da Silva, Cristiana | pt |
dc.contributor.author | Ribeiro, Leonardo B. | pt |
dc.contributor.author | Furuno, Caio C. | pt |
dc.contributor.author | da Cunha, Gislaine A. | pt |
dc.contributor.author | de Souza, Ronan F. F. | pt |
dc.contributor.author | Netto, Adelino V. G. | pt |
dc.contributor.author | Mauro, Antonio E. | pt |
dc.contributor.author | Frem, Regina C. G. | pt |
dc.contributor.author | Fernandes, Jose A. | pt |
dc.contributor.author | Almeida Paz, Filipe A. | pt |
dc.contributor.author | Marino, Leonardo B. | pt |
dc.contributor.author | Pavan, Fernando R. | pt |
dc.contributor.author | Leite, Clarice Q. F. | pt |
dc.date.accessioned | 2017-12-07T19:52:43Z | - |
dc.date.issued | 2015 | pt |
dc.identifier.issn | 0277-5387 | pt |
dc.identifier.uri | http://hdl.handle.net/10773/20595 | - |
dc.description.abstract | Complexes of the type trans-[PdCl2(HL)(PPh3)], where HL = pyrazole (1); 3,5-dimethylpyrazole (2); 4-nitropyrazole (3); 4-iodopyrazole (4) and PPh3 = triphenylphosphine, were synthesized and characterized by elemental analyses, infrared and H-1 NMR spectroscopies. Single-crystal X-ray diffraction determination on 3.0.9 CHCl3 and 4 showed that the coordination geometry around Pd(II) is nearly square-planar, with the chloro ligands in a trans configuration. In vitro antimycobacterial evaluation demonstrated that compound 4 displayed a minimum inhibitory concentration (MIC) of 7.61 +/- 2.18 mu M, being superior to the values observed for some commonly used antituberculosis drugs and other metal-based complexes. (C) 2015 Elsevier Ltd. All rights reserved. | pt |
dc.language.iso | eng | pt |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147332/PT | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F63736%2F2009/PT | pt |
dc.rights | restrictedAccess | por |
dc.subject | TUBERCULOSIS PANTOTHENATE SYNTHETASE | pt |
dc.subject | ALAMAR BLUE ASSAY | pt |
dc.subject | MYCOBACTERIUM-TUBERCULOSIS | pt |
dc.subject | PALLADIUM(II) COMPLEXES | pt |
dc.subject | BIOLOGICAL EVALUATION | pt |
dc.subject | STRUCTURAL-CHARACTERIZATION | pt |
dc.subject | SUPRAMOLECULAR CHEMISTRY | pt |
dc.subject | N BOND | pt |
dc.subject | LIGANDS | pt |
dc.subject | INHIBITORS | pt |
dc.title | Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity | pt |
dc.type | article | pt |
dc.peerreviewed | yes | pt |
ua.distribution | international | pt |
degois.publication.firstPage | 10 | pt |
degois.publication.lastPage | 16 | pt |
degois.publication.title | POLYHEDRON | pt |
degois.publication.volume | 100 | pt |
dc.date.embargo | 10000-01-01 | - |
dc.relation.publisherversion | 10.1016/j.poly.2015.07.009 | pt |
dc.identifier.doi | 10.1016/j.poly.2015.07.009 | pt |
Appears in Collections: | CICECO - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Pyrazolyl Pd(II) complexes containing triphenylphosphine Synthesis and antimycobacterial activity_10.1016j.poly.2015.07.009.pdf | 705.42 kB | Adobe PDF |
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