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http://hdl.handle.net/10773/20595| Title: | Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity |
| Author: | da Silva, Cristiana Ribeiro, Leonardo B. Furuno, Caio C. da Cunha, Gislaine A. de Souza, Ronan F. F. Netto, Adelino V. G. Mauro, Antonio E. Frem, Regina C. G. Fernandes, Jose A. Almeida Paz, Filipe A. Marino, Leonardo B. Pavan, Fernando R. Leite, Clarice Q. F. |
| Keywords: | TUBERCULOSIS PANTOTHENATE SYNTHETASE ALAMAR BLUE ASSAY MYCOBACTERIUM-TUBERCULOSIS PALLADIUM(II) COMPLEXES BIOLOGICAL EVALUATION STRUCTURAL-CHARACTERIZATION SUPRAMOLECULAR CHEMISTRY N BOND LIGANDS INHIBITORS |
| Issue Date: | 2015 |
| Publisher: | PERGAMON-ELSEVIER SCIENCE LTD |
| Abstract: | Complexes of the type trans-[PdCl2(HL)(PPh3)], where HL = pyrazole (1); 3,5-dimethylpyrazole (2); 4-nitropyrazole (3); 4-iodopyrazole (4) and PPh3 = triphenylphosphine, were synthesized and characterized by elemental analyses, infrared and H-1 NMR spectroscopies. Single-crystal X-ray diffraction determination on 3.0.9 CHCl3 and 4 showed that the coordination geometry around Pd(II) is nearly square-planar, with the chloro ligands in a trans configuration. In vitro antimycobacterial evaluation demonstrated that compound 4 displayed a minimum inhibitory concentration (MIC) of 7.61 +/- 2.18 mu M, being superior to the values observed for some commonly used antituberculosis drugs and other metal-based complexes. (C) 2015 Elsevier Ltd. All rights reserved. |
| Peer review: | yes |
| URI: | http://hdl.handle.net/10773/20595 |
| DOI: | 10.1016/j.poly.2015.07.009 |
| ISSN: | 0277-5387 |
| Publisher Version: | 10.1016/j.poly.2015.07.009 |
| Appears in Collections: | CICECO - Artigos |
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|---|---|---|---|---|
| Pyrazolyl Pd(II) complexes containing triphenylphosphine Synthesis and antimycobacterial activity_10.1016j.poly.2015.07.009.pdf | 705.42 kB | Adobe PDF |  |
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