Please use this identifier to cite or link to this item:
|Title:||Synthesis and Ring Transformation of Oxygen and Nitrogen Spiro Bisheterocycles|
Pinto, Diana C. G. A.
Almeida Paz, Filipe A.
Silva, Artur M. S.
oxygen and nitrogen heterocycles
|Publisher:||GEORG THIEME VERLAG KG|
|Abstract:||A facile and rapid access to bridgehead oxygen-and nitrogen-containing spiro bisheterocycles is reported. It involves a one-pot spiro-to-spiro ring transformation of the key spiro[chromanone-hydantoin] compounds into new substituted spiro [hydantoin-diazole], spiro [hydantoin-isoxazole], spiro [hydantoin-diazepine], spiro [hydantoinoxazepine], and spiro [hydantoin-benzodiazepine] upon reaction with appropriate bisnucleophilic agents. The hydantoin cycle is preserved during these chemical reactions affording the spiro bisheterocycles in optimal yields (42-71%). This relevant spiro-to-spiro ring transformation was confirmed by NMR and single-crystal X-ray diffraction studies.|
|Appears in Collections:||CICECO - Artigos|
Files in This Item:
|Synthesis and Ring Transformation of Oxygen and Nitrogen Spiro Bisheterocycles_10.1055s-0034-1379613.pdf||411.12 kB||Adobe PDF||View/Open|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.