Please use this identifier to cite or link to this item:
http://hdl.handle.net/10773/20271
Title: | Dual functionality of phosphonic-acid-appended phthalocyanines: inhibitors of urokinase plasminogen activator and anticancer photodynamic agents |
Author: | Venkatramaiah, N. Pereira, Patricia M. R. Almeida Paz, Filipe A. Ribeiro, Carlos A. F. Fernandes, Rosa Tome, Joao P. C. |
Keywords: | THERAPY CANCER SYSTEM PHOTOSENSITIZERS RECEPTOR ANALOGS |
Issue Date: | 2015 |
Publisher: | ROYAL SOC CHEMISTRY |
Abstract: | Phthalocyanines (Pcs) bearing phosphonic acid groups at the periphery exhibit a potential photodynamic effect to induce photo-toxicity on human bladder cancer epithelial cells (UM-UC-3). In vitro photophysical and biological studies show high intrinsic ability to inhibit the activity of urokinase plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9). |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/20271 |
DOI: | 10.1039/c5cc06561e |
ISSN: | 1359-7345 |
Publisher Version: | 10.1039/c5cc06561e |
Appears in Collections: | CICECO - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Dual functionality of phosphonic-acid-appended phthalocyanines inhibitors of urokinase plasminogen activator and anticancer photodynamic agents_10.1039c5cc06561e.pdf | 1.1 MB | Adobe PDF |
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