Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/20271
Title: Dual functionality of phosphonic-acid-appended phthalocyanines: inhibitors of urokinase plasminogen activator and anticancer photodynamic agents
Author: Venkatramaiah, N.
Pereira, Patricia M. R.
Almeida Paz, Filipe A.
Ribeiro, Carlos A. F.
Fernandes, Rosa
Tome, Joao P. C.
Keywords: THERAPY
CANCER
SYSTEM
PHOTOSENSITIZERS
RECEPTOR
ANALOGS
Issue Date: 2015
Publisher: ROYAL SOC CHEMISTRY
Abstract: Phthalocyanines (Pcs) bearing phosphonic acid groups at the periphery exhibit a potential photodynamic effect to induce photo-toxicity on human bladder cancer epithelial cells (UM-UC-3). In vitro photophysical and biological studies show high intrinsic ability to inhibit the activity of urokinase plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9).
Peer review: yes
URI: http://hdl.handle.net/10773/20271
DOI: 10.1039/c5cc06561e
ISSN: 1359-7345
Publisher Version: 10.1039/c5cc06561e
Appears in Collections:CICECO - Artigos



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