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http://hdl.handle.net/10773/20191
Title: | Evaluating structural and microstructural changes of PDMS-SiO2 hybrid materials after sterilization by gamma irradiation |
Author: | Carlos Almeida, J. Lancastre, Joana Helena Vaz Fernandes, M. Margaca, Fernanda M. A. Ferreira, Luis Miranda Salvado, Isabel M. |
Keywords: | MODIFIED CAO-SIO2-TIO2 HYBRIDS NUCLEAR-MAGNETIC-RESONANCE SI-29 NMR IN-VITRO FT-IR SILOXANE POLYDIMETHYLSILOXANE NANOCOMPOSITES HYDROLYSIS TEOS |
Issue Date: | 2015 |
Publisher: | ELSEVIER SCIENCE BV |
Abstract: | PDMS-SiO2 hybrid materials obtained by sol-gel process have been extensively studied over the past years due to its promising biomedical applications namely as bone substitutes, catheters, and drug delivery devices. Regardless of the intended biomedical application, all these materials should go through a sterilization process before interfacing with a living structure. However, it is unclear whether they undergo structural and microstructural changes when subjected to sterilization by gamma irradiation. This paper addresses this issue by showing that a sol-gel processed biomaterial based on the PDMS-CaO-SiO2 hybrid system suffers only small structural changes when submitted to a radiation dose of 25 kGy, the dose usually recommended to achieve a Sterility Assurance Level of 10(-6) when the natural contamination level and microorganism types cannot be calculated. The characterization was assessed by FT-IR, Si-29-{H-1} CP-MAS, thermal analysis (DTG), and SEM. (C) 2014 Elsevier B.V. All rights reserved. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/20191 |
DOI: | 10.1016/j.msec.2014.12.025 |
ISSN: | 0928-4931 |
Publisher Version: | 10.1016/j.msec.2014.12.025 |
Appears in Collections: | CICECO - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Evaluating structural and microstructural changes of PDMS-SiO2 hybrid materials after sterilization by gamma irradiation_10.1016j.msec.2014.12.025.pdf | 617.69 kB | Adobe PDF |
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