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http://hdl.handle.net/10773/20183
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DC Field | Value | Language |
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dc.contributor.author | Dhau, Jaspreet S. | pt |
dc.contributor.author | Singh, Avtar | pt |
dc.contributor.author | Singh, Amritpal | pt |
dc.contributor.author | Sharma, Neha | pt |
dc.contributor.author | Brandao, Paula | pt |
dc.contributor.author | Felix, Vitor | pt |
dc.contributor.author | Singh, Baljinder | pt |
dc.contributor.author | Sharma, Vishal | pt |
dc.date.accessioned | 2017-12-07T19:38:18Z | - |
dc.date.available | 2017-12-07T19:38:18Z | - |
dc.date.issued | 2015 | pt |
dc.identifier.issn | 2046-2069 | pt |
dc.identifier.uri | http://hdl.handle.net/10773/20183 | - |
dc.description.abstract | The reaction of bis(organyl)diselenide with a reducing agent, such as LiAlH4, NaBH4, Li(C2H5)(3)BH, etc., generally leads to cleavage of the Se-Se bond resulting in the formation of the corresponding organylselenols/selenolates. However, this work for the first time demonstrates the scisson of the C-(pyridine)-Se bond in bis(2-pyridyl)diselenides with LiAlH4. The reaction affords analytically pure bis(2-pyridyl)selenides in near quantitative yields. The reaction pathway involves the formation of a selenated aluminato complex followed by the scission of the C-(pyridine)-Se bond and generation of LiAlSeH2. The generation of LiAlSeH2 was established by experimental and NMR analysis. The mechanism of the reaction has been supported by theoretical analysis. Single crystal X-ray structure determination of bis(3-methyl-2-pyridyl)selenide (2e) was performed and it shows that the molecules are self-assembled in a 2D-network of CH center dot center dot center dot N hydrogen bonds and pi center dot center dot center dot pi stacking interactions. The synthesized compounds were also evaluated against the Raji cancer cell line (acute lymphoid leukemia). | pt |
dc.language.iso | eng | pt |
dc.publisher | ROYAL SOC CHEMISTRY | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147332/PT | pt |
dc.rights | openAccess | por |
dc.subject | ONE-FLASK SYNTHESIS | pt |
dc.subject | PYRIDYLSELENIUM COMPOUNDS | pt |
dc.subject | MOLECULAR PRECURSORS | pt |
dc.subject | THIN-FILMS | pt |
dc.subject | DERIVATIVES | pt |
dc.subject | SELENIUM | pt |
dc.subject | NANOCRYSTALS | pt |
dc.subject | LITHIATION | pt |
dc.subject | PYRIDYL | pt |
dc.subject | DIALKYL | pt |
dc.title | A mechanistic study of the synthesis, single crystal X-ray data and anticarcinogenic potential of bis(2-pyridyl)selenides and -diselenides | pt |
dc.type | article | pt |
dc.peerreviewed | yes | pt |
ua.distribution | international | pt |
degois.publication.firstPage | 78669 | pt |
degois.publication.issue | 96 | pt |
degois.publication.lastPage | 78676 | pt |
degois.publication.title | RSC ADVANCES | pt |
degois.publication.volume | 5 | pt |
dc.relation.publisherversion | 10.1039/c5ra15577k | pt |
dc.identifier.doi | 10.1039/c5ra15577k | pt |
Appears in Collections: | CICECO - Artigos |
Files in This Item:
File | Description | Size | Format | |
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A mechanistic study of the synthesis single crystal X-ray data and anticarcinogenic potential of bis(2-pyridyl)selenides and -diselenides_10.1039c5ra15577k.pdf | 1.57 MB | Adobe PDF | View/Open |
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