Please use this identifier to cite or link to this item:
http://hdl.handle.net/10773/20043
Title: | Fluorescent Magnetic Bioprobes by Surface Modification of Magnetite Nanoparticles |
Author: | Pinheiro, Paula C. Daniel-da-Silva, Ana L. Tavares, Daniela S. Pilar Calatayud, M. Goya, Gerardo F. Trindade, Tito |
Keywords: | IRON-OXIDE NANOPARTICLES DRUG-DELIVERY BIOMEDICAL APPLICATIONS INTRACELLULAR UPTAKE SILICA SPHERES PARTICLES LUMINESCENT CELLS LAYER |
Issue Date: | 2013 |
Publisher: | MDPI AG |
Abstract: | Bimodal nanoprobes comprising both magnetic and optical functionalities have been prepared via a sequential two-step process. Firstly, magnetite nanoparticles (MNPs) with well-defined cubic shape and an average dimension of 80 nm were produced by hydrolysis of iron sulfate and were then surface modified with silica shells by using the sol-gel method. The Fe3O4@SiO2 particles were then functionalized with the fluorophore, fluorescein isothiocyanate (FITC), mediated by assembled shells of the cationic polyelectrolyte, polyethyleneimine (PEI). The Fe3O4 functionalized particles were then preliminary evaluated as fluorescent and magnetic probes by performing studies in which neuroblast cells have been contacted with these nanomaterials. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/20043 |
DOI: | 10.3390/ma6083213 |
ISSN: | 1996-1944 |
Publisher Version: | 10.3390/ma6083213 |
Appears in Collections: | CICECO - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Fluorescent Magnetic Bioprobes by Surface Modification of Magnetite Nanoparticles_10.3390ma6083213.pdf | 630.58 kB | Adobe PDF | View/Open |
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