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http://hdl.handle.net/10773/19966| Title: | Recycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analogues |
| Author: | Perez, Bianca C. Fernandes, Iva Mateus, Nuno Teixeira, Catia Gomes, Paula |
| Keywords: | HALF-MUSTARD DERIVATIVES PHENYL NITROGEN-MUSTARD AGENTS ACID DRUG DISTAMYCIN EXPRESSION INHIBITORS GROWTH CELLS |
| Issue Date: | 2013 |
| Publisher: | PERGAMON-ELSEVIER SCIENCE LTD |
| Abstract: | Cinnamic acids and quinolines are known as useful scaffolds in the discovery of antitumor agents. Therefore, N-cinnamoylated analogues of chloroquine, recently reported as potent dual-action antimalarials, were evaluated against three different cancer cell lines: MKN-28, Caco-2, and MCF-7. All compounds display anti-proliferative activity in the micromolar range against the three cell lines tested, and most of them were more active than their parent drug, chloroquine, against all cell lines tested. Hence, N-cinnamoyl-chloroquine analogues are a good start towards development of affordable antitumor leads. (C) 2013 Elsevier Ltd. All rights reserved. |
| Peer review: | yes |
| URI: | http://hdl.handle.net/10773/19966 |
| DOI: | 10.1016/j.bmcl.2013.10.025 |
| ISSN: | 0960-894X |
| Publisher Version: | 10.1016/j.bmcl.2013.10.025 |
| Appears in Collections: | CICECO - Artigos |
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| Recycling antimalarial leads for cancer Antiproliferative properties of N-cinnamoyl chloroquine analogues_10.1016j.bmcl.2013.10.025.pdf | 283.78 kB | Adobe PDF |  |
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