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http://hdl.handle.net/10773/19837
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Braga, Susana S. | pt |
dc.contributor.author | Mokal, Vijaya | pt |
dc.contributor.author | Almeida Paz, Filipe A. | pt |
dc.contributor.author | Pillinger, Martyn | pt |
dc.contributor.author | Branco, Ana F. | pt |
dc.contributor.author | Sardao, Vilma A. | pt |
dc.contributor.author | Diogo, Catia V. | pt |
dc.contributor.author | Oliveira, Paulo J. | pt |
dc.contributor.author | Marques, Maria P. M. | pt |
dc.contributor.author | Romao, Carlos C. | pt |
dc.contributor.author | Goncalves, Isabel S. | pt |
dc.date.accessioned | 2017-12-07T19:26:31Z | - |
dc.date.issued | 2014 | pt |
dc.identifier.issn | 1434-1948 | pt |
dc.identifier.uri | http://hdl.handle.net/10773/19837 | - |
dc.description.abstract | The complexes [(eta(5)-C5H4-CO-R)Mo(CO)(2)(eta(3)-C3H5)] [R = OH (1), Phe OMe (2)] have been examined as guests for the cyclodextrin (CD) hosts beta-CD and heptakis(2,3,6-tri-O-methyl)-beta-CD (TRIMEB), and the resultant inclusion compounds have been characterised in the solid state by elemental and thermogravimetric analyses, powder X-ray diffraction, C-13{H-1) cross-polarisation (CP) magic angle spinning (MAS) NM R spectroscopy and ITTIR spectroscopy. Singlecrystal X-ray analysis of 1 shows that the unit cell contains centrosymmetric supramolecular dimers comprising two di- carlx)nyl complexes linked through hydrogen-bonding interactions involving the carboxylic acid groups. In screening tests for antiproliferative effects, the Cl) adducts containing 1 displayed enhanced antitumour activity against mouse melanoma (when compared with nonincluded 1), while showing minimal activity towards human adenocarcinoma and nontumour rat myoblast cell lines. TRIMEB encapsulation resulted in a predominant toxic effect on tumour cells versus the rion-neoplastic rriyoblasl cells. | pt |
dc.language.iso | eng | pt |
dc.publisher | WILEY-V C H VERLAG GMBH | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/COMPETE/132936/PT | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/127348/PT | pt |
dc.rights | restrictedAccess | por |
dc.subject | ORGANOMETALLIC CONFORMATIONAL EQUILIBRIA | pt |
dc.subject | CAMBRIDGE STRUCTURAL DATABASE | pt |
dc.subject | RING INDENYL ANALOGS | pt |
dc.subject | BETA-CYCLODEXTRIN | pt |
dc.subject | CRYSTAL-STRUCTURES | pt |
dc.subject | ALLYL COMPLEXES | pt |
dc.subject | MIXED-RING | pt |
dc.subject | MOLYBDENUM COMPLEXES | pt |
dc.subject | CATALYST PRECURSORS | pt |
dc.subject | TUNGSTEN COMPLEXES | pt |
dc.title | Synthesis, Characterisation and Antiproliferative Studies of Allyl(dicarbonyl)(cyclopentadienyl)molybdenum Complexes and Cyclodextrin Inclusion Compounds | pt |
dc.type | article | pt |
dc.peerreviewed | yes | pt |
ua.distribution | international | pt |
degois.publication.firstPage | 5034 | pt |
degois.publication.issue | 29 | pt |
degois.publication.lastPage | 5045 | pt |
degois.publication.title | EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | pt |
dc.date.embargo | 10000-01-01 | - |
dc.relation.publisherversion | 10.1002/ejic.201402540 | pt |
dc.identifier.doi | 10.1002/ejic.201402540 | pt |
Appears in Collections: | CICECO - Artigos |
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