Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/19767
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dc.contributor.authorBouaziz, Omarpt
dc.contributor.authorAmari, Mohamedpt
dc.contributor.authorBachar, Rebatpt
dc.contributor.authorKhier, Nawalpt
dc.contributor.authorFodili, Mokhtarpt
dc.contributor.authorAlmeida Paz, Filipe A.pt
dc.contributor.authorTalhi, Oualidpt
dc.contributor.authorSilva, Artur M. S.pt
dc.date.accessioned2017-12-07T19:24:08Z-
dc.date.issued2015pt
dc.identifier.issn0040-4039pt
dc.identifier.urihttp://hdl.handle.net/10773/19767-
dc.description.abstractA two-step procedure transformation starting from the reaction of ortho-phenylenediamines on 2-acetylbutyrolactone 1 yielded (Z)-3-(1-aminoethylidene)butyrolactones 2, which were treated with either N,N-dimethylformamide dimethyl acetal, triphosgene, or carbon disulfide under different reaction conditions to produce a new series of benzimidazole-, benzimidazolone-, or benzimidazole-2-thione-butyrolactone dyads 3-5, respectively. The structures of compounds 2-5 were established by NMR and mass spectrometry. The isolation of important reaction intermediates as single-crystals allowed the determination of the (Z)-configuration in the resulting conjugate heterocyclic systems 3-5 by X-ray diffraction studies. (C) 2015 Elsevier Ltd. All rights reserved.pt
dc.language.isoengpt
dc.publisherElsevierpt
dc.relationinfo:eu-repo/grantAgreement/FCT/COMPETE/132997/PTpt
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147332/PTpt
dc.rightsrestrictedAccesspor
dc.subjectMethylene-gamma-butyrolactonespt
dc.subjectBridgehead nitrogen atompt
dc.subjectHeterocyclic-systemspt
dc.subjectDerivativespt
dc.subjectAcidpt
dc.subjectThiazolo<3,2-a>Benzimidazol-3(2h)-Onespt
dc.subjectInhibitorspt
dc.subjectPyrazolept
dc.subjectChromonept
dc.subjectPotentpt
dc.titleSynthesis of functionalized benzimidazole-butyrolactone dyadspt
dc.typearticlept
dc.peerreviewedyespt
ua.distributioninternationalpt
degois.publication.firstPage1020pt
degois.publication.issue8pt
degois.publication.lastPage1024pt
degois.publication.titleTetrahedron Letterspt
degois.publication.volume56pt
dc.date.embargo10000-01-01-
dc.relation.publisherversion10.1016/j.tetlet.2015.01.039pt
dc.identifier.doi10.1016/j.tetlet.2015.01.039pt
Appears in Collections:CICECO - Artigos
DQ - Artigos
QOPNA - Artigos

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