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http://hdl.handle.net/10773/19767
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bouaziz, Omar | pt |
dc.contributor.author | Amari, Mohamed | pt |
dc.contributor.author | Bachar, Rebat | pt |
dc.contributor.author | Khier, Nawal | pt |
dc.contributor.author | Fodili, Mokhtar | pt |
dc.contributor.author | Almeida Paz, Filipe A. | pt |
dc.contributor.author | Talhi, Oualid | pt |
dc.contributor.author | Silva, Artur M. S. | pt |
dc.date.accessioned | 2017-12-07T19:24:08Z | - |
dc.date.issued | 2015 | pt |
dc.identifier.issn | 0040-4039 | pt |
dc.identifier.uri | http://hdl.handle.net/10773/19767 | - |
dc.description.abstract | A two-step procedure transformation starting from the reaction of ortho-phenylenediamines on 2-acetylbutyrolactone 1 yielded (Z)-3-(1-aminoethylidene)butyrolactones 2, which were treated with either N,N-dimethylformamide dimethyl acetal, triphosgene, or carbon disulfide under different reaction conditions to produce a new series of benzimidazole-, benzimidazolone-, or benzimidazole-2-thione-butyrolactone dyads 3-5, respectively. The structures of compounds 2-5 were established by NMR and mass spectrometry. The isolation of important reaction intermediates as single-crystals allowed the determination of the (Z)-configuration in the resulting conjugate heterocyclic systems 3-5 by X-ray diffraction studies. (C) 2015 Elsevier Ltd. All rights reserved. | pt |
dc.language.iso | eng | pt |
dc.publisher | Elsevier | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/COMPETE/132997/PT | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147332/PT | pt |
dc.rights | restrictedAccess | por |
dc.subject | Methylene-gamma-butyrolactones | pt |
dc.subject | Bridgehead nitrogen atom | pt |
dc.subject | Heterocyclic-systems | pt |
dc.subject | Derivatives | pt |
dc.subject | Acid | pt |
dc.subject | Thiazolo<3,2-a>Benzimidazol-3(2h)-Ones | pt |
dc.subject | Inhibitors | pt |
dc.subject | Pyrazole | pt |
dc.subject | Chromone | pt |
dc.subject | Potent | pt |
dc.title | Synthesis of functionalized benzimidazole-butyrolactone dyads | pt |
dc.type | article | pt |
dc.peerreviewed | yes | pt |
ua.distribution | international | pt |
degois.publication.firstPage | 1020 | pt |
degois.publication.issue | 8 | pt |
degois.publication.lastPage | 1024 | pt |
degois.publication.title | Tetrahedron Letters | pt |
degois.publication.volume | 56 | pt |
dc.date.embargo | 10000-01-01 | - |
dc.relation.publisherversion | 10.1016/j.tetlet.2015.01.039 | pt |
dc.identifier.doi | 10.1016/j.tetlet.2015.01.039 | pt |
Appears in Collections: | CICECO - Artigos DQ - Artigos QOPNA - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Synthesis of functionalized benzimidazole-butyrolactone dyads_10.1016j.tetlet.2015.01.039.pdf | 443.56 kB | Adobe PDF |
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