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http://hdl.handle.net/10773/19550
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DC Field | Value | Language |
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dc.contributor.author | Lehtonen, Henna-Maria | pt |
dc.contributor.author | Lindstedt, Anni | pt |
dc.contributor.author | Jarvinen, Riikka | pt |
dc.contributor.author | Sinkkonen, Jari | pt |
dc.contributor.author | Graca, Goncalo | pt |
dc.contributor.author | Viitanen, Matti | pt |
dc.contributor.author | Kallio, Heikki | pt |
dc.contributor.author | Gil, Ana M. | pt |
dc.date.accessioned | 2017-12-07T19:16:31Z | - |
dc.date.issued | 2013 | pt |
dc.identifier.issn | 0308-8146 | pt |
dc.identifier.uri | http://hdl.handle.net/10773/19550 | - |
dc.description.abstract | The use of NMR metabolomics in clinical trials is growing; however, reports of postprandial experiments in humans are scarce. The present study investigated whether consumption of lingonberries as a supplement to an oil-rich meal modifies the postprandial fingerprints of human urine. Urine samples were analysed by H-1 NMR, and untargeted multivariate analysis was applied to the data for comprehensive fingerprinting. A clear separation of postprandial lingonberry meal samples was revealed. To evaluate statistical differences, a targeted approach was applied for the informative spectral areas. Significantly (p < 0.05) increased levels of polyphenol metabolites, hippuric acid and 4-hydroxyhippuric acid, and decreased creatinine and dimethylamine levels were the major explanations for the grouping of the postprandial samples after the different meals. Thus, inclusion of polyphenol-rich lingonberry powder in a rapeseed oil-rich meal modifies the metabolic profile of urine which may be used to reveal both consumption of berries and health-promoting changes in the common metabolism. (C) 2012 Elsevier Ltd. All rights reserved. | pt |
dc.language.iso | eng | pt |
dc.publisher | ELSEVIER SCI LTD | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F41869%2F2007/PT | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/COMPETE/132936/PT | pt |
dc.rights | restrictedAccess | por |
dc.subject | PLASMA ASYMMETRIC DIMETHYLARGININE | pt |
dc.subject | FRUIT ACIDS | pt |
dc.subject | POLYPHENOLS | pt |
dc.subject | HUMANS | pt |
dc.subject | JUICE | pt |
dc.subject | EXCRETION | pt |
dc.subject | CRANBERRY | pt |
dc.subject | SUGARS | pt |
dc.title | H-1 NMR-based metabolic fingerprinting of urine metabolites after consumption of lingonberries (Vaccinium vitis-idaea) with a high-fat meal | pt |
dc.type | article | pt |
dc.peerreviewed | yes | pt |
ua.distribution | international | pt |
degois.publication.firstPage | 982 | pt |
degois.publication.issue | 982-990 | pt |
degois.publication.lastPage | 990 | pt |
degois.publication.title | FOOD CHEMISTRY | pt |
degois.publication.volume | 138 | pt |
dc.date.embargo | 10000-01-01 | - |
dc.relation.publisherversion | 10.1016/j.foodchem.2012.10.081 | pt |
dc.identifier.doi | 10.1016/j.foodchem.2012.10.081 | pt |
Appears in Collections: | CICECO - Artigos |
Files in This Item:
File | Description | Size | Format | |
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1H NMR-based metabolic fingerprinting of urine metabolites after consumption of lingonberries (Vaccinium vitis-idaea) with a high-fat meal_10.1016j.foodchem.2012.10.081.pdf | 463.89 kB | Adobe PDF |
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