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http://hdl.handle.net/10773/19550
Título: | H-1 NMR-based metabolic fingerprinting of urine metabolites after consumption of lingonberries (Vaccinium vitis-idaea) with a high-fat meal |
Autor: | Lehtonen, Henna-Maria Lindstedt, Anni Jarvinen, Riikka Sinkkonen, Jari Graca, Goncalo Viitanen, Matti Kallio, Heikki Gil, Ana M. |
Palavras-chave: | PLASMA ASYMMETRIC DIMETHYLARGININE FRUIT ACIDS POLYPHENOLS HUMANS JUICE EXCRETION CRANBERRY SUGARS |
Data: | 2013 |
Editora: | ELSEVIER SCI LTD |
Resumo: | The use of NMR metabolomics in clinical trials is growing; however, reports of postprandial experiments in humans are scarce. The present study investigated whether consumption of lingonberries as a supplement to an oil-rich meal modifies the postprandial fingerprints of human urine. Urine samples were analysed by H-1 NMR, and untargeted multivariate analysis was applied to the data for comprehensive fingerprinting. A clear separation of postprandial lingonberry meal samples was revealed. To evaluate statistical differences, a targeted approach was applied for the informative spectral areas. Significantly (p < 0.05) increased levels of polyphenol metabolites, hippuric acid and 4-hydroxyhippuric acid, and decreased creatinine and dimethylamine levels were the major explanations for the grouping of the postprandial samples after the different meals. Thus, inclusion of polyphenol-rich lingonberry powder in a rapeseed oil-rich meal modifies the metabolic profile of urine which may be used to reveal both consumption of berries and health-promoting changes in the common metabolism. (C) 2012 Elsevier Ltd. All rights reserved. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/19550 |
DOI: | 10.1016/j.foodchem.2012.10.081 |
ISSN: | 0308-8146 |
Versão do Editor: | 10.1016/j.foodchem.2012.10.081 |
Aparece nas coleções: | CICECO - Artigos |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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1H NMR-based metabolic fingerprinting of urine metabolites after consumption of lingonberries (Vaccinium vitis-idaea) with a high-fat meal_10.1016j.foodchem.2012.10.081.pdf | 463.89 kB | Adobe PDF |
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