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http://hdl.handle.net/10773/19376
Title: | Multifunctional materials for bone cancer treatment |
Author: | Marques, Catarina Ferreira, Jose M. F. Andronescu, Ecaterina Ficai, Denisa Sonmez, Maria Ficai, Anton |
Keywords: | DRUG-DELIVERY SYSTEMS COLLAGEN/HYDROXYAPATITE COMPOSITE-MATERIALS SYNTHESIZED IN-VITRO LOCAL-DELIVERY HYDROXYAPATITE/COLLAGEN COMPOSITE MAGNETITE NANOPARTICLES BIOMEDICAL APPLICATIONS STAPHYLOCOCCUS-AUREUS POROUS HYDROXYAPATITE COLLAGEN COMPOSITES |
Issue Date: | 2014 |
Publisher: | DOVE MEDICAL PRESS LTD |
Abstract: | The purpose of this review is to present the most recent findings in bone tissue engineering. Special attention is given to multifunctional materials based on collagen and collagen-hydroxyapatite composites used for skin and bone cancer treatments. The multi-functionality of these materials was obtained by adding to the base regenerative grafts proper components, such as ferrites (magnetite being the most important representative), cytostatics (cisplatin, carboplatin, vincristine, methotrexate, paclitaxel, doxorubicin), silver nanoparticles, antibiotics (anthracyclines, geldanamycin), and/or analgesics (ibuprofen, fentanyl). The suitability of complex systems for the intended applications was systematically analyzed. The developmental possibilities of multifunctional materials with regenerative and curative roles (antitumoral as well as pain management) in the field of skin and bone cancer treatment are discussed. It is worth mentioning that better materials are likely to be developed by combining conventional and unconventional experimental strategies. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/19376 |
DOI: | 10.2147/IJN.S55943 |
ISSN: | 1178-2013 |
Publisher Version: | 10.2147/IJN.S55943 |
Appears in Collections: | CICECO - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Multifunctional materials for bone cancer treatment_10.2147IJN.S55943.pdf | 1.18 MB | Adobe PDF | View/Open |
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