Please use this identifier to cite or link to this item:
http://hdl.handle.net/10773/19340
Title: | N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents |
Author: | Vale-Costa, S. Costa-Gouveia, J. Perez, B. Silva, T. Teixeira, C. Gomes, P. Gomes, M. S. |
Keywords: | VISCERAL LEISHMANIASIS DIAGNOSIS DRUGS |
Issue Date: | 2013 |
Publisher: | AMER SOC MICROBIOLOGY |
Abstract: | A series of cinnamic acid conjugates of primaquine and chloroquine were evaluated for their in vitro antileishmanial activities. Although primaquine derivatives had modest activity, chloroquine conjugates exhibited potent activity against both promastigotes (50% inhibitory concentration [IC50] = 2.6 to 21.8 mu M) and intramacrophagic amastigotes (IC50 = 1.2 to 9.3 mu M) of Leishmania infantum. Both the high activity of these chloroquine analogues and their mild-to-low toxicity toward host cells make them promising leads for the discovery of new antileishmanial agents. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/19340 |
DOI: | 10.1128/AAC.00557-13 |
ISSN: | 0066-4804 |
Publisher Version: | 10.1128/AAC.00557-13 |
Appears in Collections: | CICECO - Artigos |
Files in This Item:
File | Description | Size | Format | |
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N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents_10.1128AAC.00557-13.pdf | 181.01 kB | Adobe PDF | View/Open |
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