Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/19320
Title: Studies on polymorph conversion in a new cyclodextrin inclusion compound
Author: Fernandes, Jose A.
Ramos, Ana I.
Ribeiro-Claro, Paulo
Paz, Filipe A. Almeida
Braga, Susana S.
Keywords: N-OXIDE DERIVATIVES
METAL-ORGANIC FRAMEWORKS
C-13 CHEMICAL-SHIFTS
BETA-CYCLODEXTRIN
SOLID-STATE
AQUEOUS-SOLUTION
ANTIMICROBIAL ACTIVITY
ALLIUM-STIPITATUM
SOLUTION NMR
COMPLEX
Issue Date: 2015
Publisher: ROYAL SOC CHEMISTRY
Abstract: A novel beta-cyclodextrin (beta CD) inclusion compound was prepared using 4-phenylpyridine-N-oxide (PPNO) as the organic guest. The inclusion compound, beta CD.PPNO, was characterised both in solution and in the solid state using numerous techniques. H-1 NMR in aqueous solution allowed the determination of a 1 : 1 stoichiometry and an association constant of 164 +/- 21 M-1. Powder and single-crystal X-ray diffraction studies showed the formation of two distinct crystal phases, appearing at different timings. Over time, one of the crystal phases converts spontaneously into the other. This work is the first to monitor the conversion of different polymorphs of cyclodextrin inclusion compounds in real time.
Peer review: yes
URI: http://hdl.handle.net/10773/19320
DOI: 10.1039/c4ce02041c
ISSN: 1466-8033
Publisher Version: 10.1039/c4ce02041c
Appears in Collections:CICECO - Artigos

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