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Title: Prediction of Gestational Diabetes through NMR Metabolomics of Maternal Blood
Author: Pinto, Joana
Almeida, Lara M
Martins, Ana S
Duarte, Daniela
Barros, Antonio S
Gahano, Eulalia
Pita, Cristina
Almeida, Maria do Ceu
Carreira, Isabel M
Gil, Ana M
Keywords: Pregnancy
Gestational diabetes mellitus (GDM)
Prediagnosis GDM
Maternal plasma
Lipid extracts
Issue Date: 2015
Publisher: American Chemical Society
Abstract: Metabolic biomarkers of pre- and postdiagnosis gestational diabetes mellitus (GDM) were sought, using nuclear magnetic resonance (NMR) metabolomics of maternal plasma and corresponding lipid extracts. Metabolite differences between controls and disease were identified through multivariate analysis of variable selected 1H NMR spectra. For postdiagnosis GDM, partial least squares regression identified metabolites with higher dependence on normal gestational age evolution. Variable selection of NMR spectra produced good classification models for both pre- and postdiagnostic GDM. Prediagnosis GDM was accompanied by cholesterol increase and minor increases in lipoproteins (plasma), fatty acids, and triglycerides (extracts). Small metabolite changes comprised variations in glucose (up regulated), amino acids, betaine, urea, creatine, and metabolites related to gut microflora. Most changes were enhanced upon GDM diagnosis, in addition to newly observed changes in low-Mw compounds. GDM prediction seems possible e...
Peer review: yes
DOI: 10.1021/acs.jproteome.5b00260
ISSN: 1535-3907
Appears in Collections:CICECO - Artigos

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