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Title: Impact of fetal chromosomal disorders on maternal blood metabolome: toward new biomarkers?
Author: Pinto, Joana
Almeida, Lara Monteiro
Martins, Ana Sofia
Duarte, Daniela
Marques Domingues, Maria Rosario
Barros, Antonio Sousa
Galhano, Eulalia
Pita, Cristina
Almeida, Maria do Ceu
Carreira, Isabel Marques
Gil, Ana Maria
Keywords: Chromosomal disorders
Lipid extracts
Maternal plasma
Nuclear magnetic resonance metabolomics
Trisomy 21
Issue Date: 2015
Publisher: Elsevier
Abstract: This study aimed at determining the relationship between fetal chromosomal disorders (CDs), including trisomy 21 (T21), and on first and second trimester maternal blood plasma, to identify the time course metabolic adaptations to the conditions and the possible new plasma biomarkers. Furthermore, a definition of a joint circulatory (plasma) and excretory (urine) metabolic description of second trimester CDs was sought.
Peer review: yes
DOI: 10.1016/j.ajog.2015.07.032
ISSN: 1097-6868
Appears in Collections:CICECO - Artigos

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