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http://hdl.handle.net/10773/18177| Title: | Impact of fetal chromosomal disorders on maternal blood metabolome: toward new biomarkers? |
| Author: | Pinto, Joana Almeida, Lara Monteiro Martins, Ana Sofia Duarte, Daniela Marques Domingues, Maria Rosario Barros, Antonio Sousa Galhano, Eulalia Pita, Cristina Almeida, Maria do Ceu Carreira, Isabel Marques Gil, Ana Maria |
| Keywords: | Chromosomal disorders Lipid extracts Maternal plasma Nuclear magnetic resonance metabolomics Pregnancy Trisomy 21 |
| Issue Date: | 2015 |
| Publisher: | Elsevier |
| Abstract: | This study aimed at determining the relationship between fetal chromosomal disorders (CDs), including trisomy 21 (T21), and on first and second trimester maternal blood plasma, to identify the time course metabolic adaptations to the conditions and the possible new plasma biomarkers. Furthermore, a definition of a joint circulatory (plasma) and excretory (urine) metabolic description of second trimester CDs was sought. |
| Peer review: | yes |
| URI: | http://hdl.handle.net/10773/18177 |
| DOI: | 10.1016/j.ajog.2015.07.032 |
| ISSN: | 1097-6868 |
| Appears in Collections: | CICECO - Artigos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Impact of fetal chromosomal disorders on maternal blood metabolome toward new biomarkers_10.1016j.ajog.2015.07.032.pdf | 2.15 MB | Adobe PDF |  |
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