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Title: The effects of carbamazepine on macroinvertebrate species: comparing bivalves and polychaetes biochemical responses
Author: Freitas, Rosa
Almeida, Ângela
Pires, Adília
Velez, Cátia
Calisto, Vânia
Schneider, Rudolf J.
Esteves, Valdemar I.
Wrona, Frederick J.
Figueira, Etelvina
Soares, Amadeu M. V. M.
Keywords: Biomarkers
Oxidative stress
Scrobicularia plana
Diopatra neapolitana
Pharmaceutical drugs
Issue Date: 2015
Publisher: Elsevier
Abstract: In the present study, the bivalve Scrobicularia plana and the polychaete Diopatra neapolitana were exposed to an increasing carbamazepine (CBZ) concentration gradient. Both species are among the most widely used bioindicators, and CBZ is one of the most commonly found drugs in the aquatic environment. After a chronic exposure (28 days), the results obtained revealed that CBZ induced biochemical alterations in both species. Our findings demonstrated that S. plana and D. neapolitana reduced the CBZ accumulation rate at higher CBZ concentrations, probably due to their capacity to decrease their feeding rates at stressful conditions. Nevertheless, this defence mechanism was not enough to prevent both species from oxidative stress. In fact, S. plana and D. neapolitana were not able to efficiently activate their antioxidant defence mechanisms which resulted in the increase of lipid peroxidation, especially at the highest CBZ concentrations. Comparing both species, it seems that S. plana was the most sensitive species since stronger biochemical alterations were observed in this species.
Peer review: yes
DOI: 10.1016/j.watres.2015.08.003
ISSN: 0043-1354
Appears in Collections:CESAM - Artigos
DBio - Artigos
DQ - Artigos

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