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Title: Perturbations in ROS-related processes of the fish Gambusia holbrooki after acute and chronic exposures to the metals copper and cadmium
Author: Nunes, Bruno
Caldeira, Carina
Pereira, Joana Luísa
Gonçalves, Fernando
Correia, Alberto Teodorico
Keywords: Freshwater fish
Oxidative stress
Ecologically relevant exposure
Mosquito fish
Issue Date: 2015
Publisher: Springer
Abstract: Metallic contamination is a widespread phenomena, particularly in areas impacted by human activities, and has become a relevant environmental concern. However, the toxicity of metals on fish requires full characterization in terms of short- and long-term effects. Thus, the purpose of this study was to determine the acute and chronic oxidative stress response in liver and gills of Gambusia holbrooki exposed to copper and cadmium. To assess the effects of these twometals, we adopted a strategy of analyzing the pollution effects caused by salts of the two metallic elements, and we quantified the oxidative stress biomarkers catalase, glutathione reductase, glutathione-S-transferases, and lipid peroxidation after exposure (4 and 28 days) to ecologically relevant concentrations, thus simulating actual conditions of exposure in the wild. Our results showed that copper elicited strong effects in all tested biomarkers for both acute and chronic challenges. Cadmium caused a similar response and was shown to cause significant changes particularly in catalase and glutathione-S-transferases activities. These findings evidence that ecologically relevant concentrations of common anthropogenic contaminants are causative agents of serious imbalances (namely oxidative stress) that are likely to trigger life-threatening events.
Peer review: yes
DOI: 10.1007/s11356-014-3580-6
ISSN: 0944-1344
Appears in Collections:CESAM - Artigos
DBio - Artigos

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