Please use this identifier to cite or link to this item:
http://hdl.handle.net/10773/14998
Title: | Cluster analysis in phenotyping a Portuguese population |
Author: | Loureiro, Cláudia Chaves Sá-Couto, Pedro Todo-Bom, Ana Bousquet, Jean |
Keywords: | Asthma Phenotypes Cluster analysis |
Issue Date: | 2015 |
Publisher: | Elsevier |
Abstract: | Background: Unbiased cluster analysis using clinical parameters has identified asthma pheno- types. Adding inflammatory biomarkers to this analysis provided a better insight into the disease mechanisms. This approach has not yet been applied to asthmatic Portuguese patients. Aim: To identify phenotypes of asthma using cluster analysis in a Portuguese asthmatic popu- lation treated in secondary medical care. Methods: Consecutive patients with asthma were recruited from the outpatient clinic. Patients were optimally treated according to GINA guidelines and enrolled in the study. Procedures were performed according to a standard evaluation of asthma. Phenotypes were identified by cluster analysis using Ward’s clustering method. Results: Of the 72 patients enrolled, 57 had full data and were included for cluster analysis. Distribution was set in 5 clusters described as follows: cluster (C) 1, early onset mild aller- gic asthma; C2, moderate allergic asthma, with long evolution, female prevalence and mixed inflammation; C3, allergic brittle asthma in young females with early disease onset and no evidence of inflammation; C4, severe asthma in obese females with late disease onset, highly symptomatic despite low Th2 inflammation; C5, severe asthma with chronic airflow obstruction, late disease onset and eosinophilic inflammation. Conclusions: In our study population, the identified clusters were mainly coincident with other larger-scale cluster analysis. Variables such as age at disease onset, obesity, lung function, FeNO (Th2 biomarker) and disease severity were important for cluster distinction. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/14998 |
DOI: | 10.1016/j.rppnen.2015.07.006 |
ISSN: | 0873-2159 |
Appears in Collections: | CIDMA - Artigos PSG - Artigos |
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Artigo.pdf | Main article | 641.51 kB | Adobe PDF |
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