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http://hdl.handle.net/10773/14995
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DC Field | Value | Language |
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dc.contributor.author | Ferreira, Brigida Costa | pt |
dc.contributor.author | Marques, Rui Vale | pt |
dc.contributor.author | Khouri, Leila | pt |
dc.contributor.author | Santos, Tânia | pt |
dc.contributor.author | Sá-Couto, Pedro | pt |
dc.contributor.author | Lopes, Maria do Carmo | pt |
dc.date.accessioned | 2016-01-06T16:50:33Z | - |
dc.date.available | 2016-01-06T16:50:33Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1748-717X | pt |
dc.identifier.uri | http://hdl.handle.net/10773/14995 | - |
dc.description.abstract | Purpose: To evaluate the differences between three methods of classification of recurrences in patients with head and neck tumours treated with Radiation Therapy (RT). Materials and methods: 367 patients with head and neck tumours were included in the study. Tumour recurrences were delineated in the CT images taken during patient follow-up and deformable registration was used to transfer this volume into the planning CT. The methods used to classify recurrences were: methodCTV quantified the intersection volume between the recurrence and the Clinical Target Volume (CTV); methodTV quantified the intersection between the Treated Volume and the recurrence (for method CTV and TV, recurrences were classified in-field if more than 95% of their volume were inside the volume of interest, marginal if the intersection was between 20-95% and outfield otherwise); and methodCOM was based on the position of the Centre Of Mass of the recurrence. A dose assessment in the recurrence volume was also made. Results: The 2-year Kaplan-Meier locoregional recurrence incidence was 10%. Tumour recurrences occurred in 22 patients in a mean time of 16.5 ± 9.4 months resulting in 28 recurrence volumes. The percentage of in-field recurrences for methods CTV, TV and COM was 7%, 43% and 50%, respectively. Agreement between the three methods in characterizing individually in-field and marginal recurrences was found only in six cases. Methods CTV and COM agreed in 14. The percentage of outfield recurrences was 29% using all methods. For local recurrences (in-field or marginal to gross disease) the average difference between the prescribed dose and D 98% in the recurrence volume was -5.2 ± 3.5% (range: -10.1%-0.9%). Conclusions: The classification of in-field and marginal recurrences is very dependent on the method used to characterize recurrences. Using methods TV and COM the largest percentage of tumour recurrences occurred in-field in tissues irradiated with high doses. Keywords: Head and neck tumours, Radiation therapy, Characterization of tumour recurrences, Geometric methods, Dosimetric assessment | pt |
dc.language.iso | eng | pt |
dc.publisher | BioMed Central | pt |
dc.relation | CIDMA/FCT - PEst-OE/MAT/UI4106/2014 | pt |
dc.relation | FCT - PEst-C/CTM/LA0025/2011 | pt |
dc.rights | openAccess | por |
dc.subject | Head and neck tumours | pt |
dc.subject | Radiation therapy | pt |
dc.subject | Characterization of tumour recurrences | pt |
dc.subject | Geometric methods | pt |
dc.subject | Dosimetric assessment | pt |
dc.title | Assessment and topographic characterization of locoregional recurrences in head and neck tumours | pt |
dc.type | article | pt |
dc.peerreviewed | yes | pt |
ua.distribution | international | pt |
degois.publication.firstPage | 10 | pt |
degois.publication.lastPage | 41 | pt |
degois.publication.title | Radiation Oncolology | pt |
degois.publication.volume | 15 | pt |
dc.identifier.doi | 10.1186/s13014-015-0345-4 | pt |
Appears in Collections: | CIDMA - Artigos PSG - Artigos |
Files in This Item:
File | Description | Size | Format | |
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2015 Ferreira Recidives RadOncol.pdf | Main article | 579.9 kB | Adobe PDF | View/Open |
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