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http://hdl.handle.net/10773/14649
Title: | Multiobjective approach to optimal control for a tuberculosis model |
Author: | Denysiuk, R. Silva, C. J. Torres, D. F. M. |
Keywords: | Epidemic model Multiobjective optimization Optimal control theory Treatment strategies Tuberculosis Differential equations Disease control Ordinary differential equations Dynamics of infections Epidemic modeling Multiobjective approach Optimal control strategy System of ordinary differential equations |
Issue Date: | 2015 |
Publisher: | Taylor & Francis |
Abstract: | Mathematical modelling can help to explain the nature and dynamics of infection transmissions, as well as support a policy for implementing those strategies that are most likely to bring public health and economic benefits. The paper addresses the application of optimal control strategies in a tuberculosis model. The model consists of a system of ordinary differential equations, which considers reinfection and post-exposure interventions. We propose a multiobjective optimization approach to find optimal control strategies for the minimization of active infectious and persistent latent individuals, as well as the cost associated to the implementation of the control strategies. Optimal control strategies are investigated for different values of the model parameters. The obtained numerical results cover a whole range of the optimal control strategies, providing valuable information about the tuberculosis dynamics and showing the usefulness of the proposed approach. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/14649 |
DOI: | 10.1080/10556788.2014.994704 |
ISSN: | 1055-6788 |
Appears in Collections: | CIDMA - Artigos SCG - Artigos |
Files in This Item:
File | Description | Size | Format | |
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[314]Denysiuk_Silva_Torres.pdf | 1.03 MB | Adobe PDF |
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