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 Ras gene in marine mussels: A molecular level response to petrochemical exposure
Please use this identifier to cite or link to this item http://hdl.handle.net/10773/5513

title: Ras gene in marine mussels: A molecular level response to petrochemical exposure
authors: Lima, I.
Peck, M. R.
Rendon-Von Osten, J.
Soares, A. M. V. M.
Guilhermino, L.
Rotchell, J. M.
keywords: Ras gene
Mytilus galloprovincialis
Petroleum hydrocarbon
issue date: 2008
publisher: Elsevier
abstract: Mussels are susceptible to numerous toxicants and are often employed as bioindicators. This study investigated the status of the ras proto-oncogene in Mytilus galloprovincialis following petrochemical exposure. A M. galloprovincialis homologue of the vertebrate ras gene was isolated, showing conserved sequence in regions of functional importance and a high incidence of polymorphic variation. Mutational damage was investigated in mussels chronically exposed to the water-accommodated fraction of #4 fuel-oil (WAF), and in mussels collected along the NW coast of Portugal in sites with different levels of petrochemical contamination. A ras gene point mutation was identified in the codon 35 of one individual exposed to 12.5% WAF No mutations were detected in mussels from the WAF control or environmental samples. This represents the first report of a ras gene mutation, experimentally-induced by petrochemical exposure, in an invertebrate species. (c) 2008 Elsevier Ltd. All rights reserved.
URI: http://hdl.handle.net/10773/5513
ISSN: 0025-326X
publisher version/DOI: http://dx.doi.org/10.1016/j.marpolbul.2008.01.018
source: Marine Pollution Bulletin
appears in collectionsBIO - Artigos
PT Mar - Artigos

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