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|title: ||Impact of magnetic nanofillers in the swelling and release properties of k-carrageenan hydrogel nanocomposites|
|authors: ||Daniel-da-Silva, Ana L.|
Estrada, Ana C.
Gil, Ana M.
|issue date: ||2012|
|abstract: ||Natural polysaccharides such as -carrageenan are an important class of biomaterials for drug delivery.
The incorporation of magnetic nanoparticles in polysaccharide hydrogels is currently being explored as
a strategy to confer to the hydrogels novel functionalities valuable for specific bio-applications. Within
this context, -carrageenan magnetic hydrogel nanocomposites have been prepared and the effect of
magnetic (Fe3O4) nanofillers in the swelling of the hydrogels and in the release kinetics and mechanism
of a model drug (methylene blue) has been investigated. In vitro release studies demonstrated the applicability
of the composites in sustained drug release. The mechanism controlling the release seems to be
determined by the strength of the gel network and the extent of gel swelling, both being affected by the
incorporation of nanofillers. Furthermore, it was demonstrated that the release rate and profile could
be tailored using variable Fe3O4 nanoparticles load. Thus, this seems to be a promising strategy for the
development of drug delivery systems with tailored released behavior.|
|publisher version/DOI: ||http://dx.doi.org/10.1016/j.carbpol.2011.07.051|
|source: ||Carbohydrate Polymers|
|appears in collections||DQ - Artigos|
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