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|title: ||Robustness of the co-ion transfer ratio in capillary electrophoresis|
|authors: ||Erny, Guillaume L.|
Esteves, Valdemar I.
|keywords: ||Indirect detection|
|issue date: ||2009|
|publisher: ||Wiley-VCH Verlag Berlin|
|abstract: ||In CE, indirect detection mode often exhibits a lower precision than its direct counterpart.
Although various explanations have already been advanced, in this work,
we aimed to investigate if this is due, in part, to problems of robustness of the coion
transfer ratio (TR), thus being inherent to this particular detection scheme. This
was investigated using simulation software that allows an accurate control of various
parameters and validated using acetic acid as a test compound. It was conclusively
demonstrated that the TR could vary by more than 6% when the concentration
of one of the ions in the BGE was changed by as few as 1%. The presence of a
system peak seems to be particularly damaging as it has been shown that the TR of
peaks whose mobilities differ by more than 0.5610– 8 m2V– 1 s – 1 from one of the system
peaks, still have a relatively low robustness.|
|publisher version/DOI: ||http://dx.doi.org/10.1002/jssc.200900069|
|source: ||Journal of Separation Science|
|appears in collections||DQ - Artigos|
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