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 Biocellulose Membranes as Supports for Dermal Release of Lidocaine
Please use this identifier to cite or link to this item http://hdl.handle.net/10773/5136

title: Biocellulose Membranes as Supports for Dermal Release of Lidocaine
authors: Trovatti, Eliane
Silva, Nuno H. C. S.
Duarte, Iola F.
Rosado, Catarina F.
Almeida, Isabel F.
Costa, Paulo
Freire, Carmen S. R.
Silvestre, Armando J. D.
Neto, Carlos Pascoal
issue date: 2011
publisher: American Chemical Society
abstract: Biocellulose (BC) is a highly pure form of cellulose, produced in the form of a swollen membrane, with several applications in the biomedical area. In this study, the behavior of BC membranes as systems for topical delivery of lidocaine was evaluated. The BC-lidocaine membranes were prepared and characterized in terms of structural and morphological properties. A uniform distribution of the drug inside the BC membranes was observed. In vitro diffusion studies with Franz cells were conducted using human epidermal membranes and showed that the permeation rate of the drug in BC membranes was slightly slower than that obtained with the conventional systems, which was attributed to the establishment of interactions between the lidocaine molecules and the BC membrane, as evidenced by FTJR and NMR analysis. These results indicate that this methodology can be successfully applied for the dermal administration of lidocaine regarding the release profile and ease of application.
URI: http://hdl.handle.net/10773/5136
ISSN: 1525-7797
publisher version/DOI: http://dx.doi.org/10.1021/bm201303r
source: Biomacromolecules
appears in collectionsDQ - Artigos

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