Please use this identifier to cite or link to this item:
http://hdl.handle.net/10773/20528
Title: | Stereoselective Synthesis of Orthogonally Protected 1,2-Diaminoinositols from D-Mannose |
Author: | Acurcio, Rita C. Soengas, Raquel G. Almeida Paz, Filipe A. Silva, Artur M. S. |
Keywords: | ONE-POT SYNTHESIS ABSOLUTE-CONFIGURATION DERIVATIVES 1,2-DIAMINES CHEMISTRY MODEL |
Issue Date: | 2014 |
Publisher: | GEORG THIEME VERLAG KG |
Abstract: | We present herein a promising novel strategy for the transformation of sugar aldehydes into 1,2-diaminoinositols. This process, based on the sequential intermolecular aza-Henry reaction and intermolecular Henry reaction allowed the total synthesis of a 1,2-diaminoinositols with total stereochemical control. The new route constitutes a simpler and more efficient approach than those previously described routes to 1,2-diaminoinositols and it has the additional advantage of offering the possibility of orthogonal protection of the amino groups. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/20528 |
DOI: | 10.1055/s-0034-1378545 |
ISSN: | 0936-5214 |
Publisher Version: | 10.1055/s-0034-1378545 |
Appears in Collections: | CICECO - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Stereoselective Synthesis of Orthogonally Protected 12-Diaminoinositols from d-Mannose_10.1055s-0034-1378545.pdf | 263.27 kB | Adobe PDF | View/Open |
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