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http://hdl.handle.net/10773/19654
Title: | Newborn Urinary Metabolic Signatures of Prematurity and Other Disorders: A Case Control Study |
Author: | Diaz, Silvia O. Pinto, Joana Barros, Antonio S. Morais, Elisabete Duarte, Daniela Negrao, Fatima Pita, Cristina Almeida, Maria do Ceu Carreira, Isabel M. Spraul, Manfred Gil, Ana M. |
Keywords: | INTRAUTERINE GROWTH-RETARDATION HYPOXIC-ISCHEMIC ENCEPHALOPATHY MAGNETIC-RESONANCE-SPECTROSCOPY NMR-BASED METABONOMICS BIRTH-WEIGHT INFANTS OXIDATIVE STRESS INBORN-ERRORS PRETERM NEWBORNS H-1-NMR PREGNANCY |
Issue Date: | 2016 |
Publisher: | AMER CHEMICAL SOC |
Abstract: | This work assesses the urinary metabolite signature of prematurity in newborns by nuclear magnetic resonance (NMR) spectroscopy, while establishing the role of possible confounders and signature specificity, through comparison to other disorders. Gender and delivery mode are shown to impact importantly on newborn urine composition, their analysis pointing out at specific metabolite variations requiring consideration in unmatched subject groups. Premature newborns are, however, characterized by a stronger signature of varying metabolites, suggestive of disturbances in nucleotide metabolism, lung surfactants biosynthesis and renal function, along with enhancement of tricarboxylic acid (TCA) cycle activity, fatty acids oxidation, and oxidative stress. Comparison with other abnormal conditions (respiratory depression episode, large for gestational age, malformations, jaundice and premature rupture of membranes) reveals that such signature seems to be largely specific of preterm newborns, showing that NMR metabolomics can retrieve particular disorder effects, as well as general stress effects. These results provide valuable novel information on the metabolic impact of prematurity, contributing to the better understanding of its effects on the newborn's state of health. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/19654 |
DOI: | 10.1021/acs.jproteome.5b00977 |
ISSN: | 1535-3893 |
Publisher Version: | 10.1021/acs.jproteome.5b00977 |
Appears in Collections: | CICECO - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Newborn Urinary Metabolic Signatures of Prematurity and Other Disorders A Case Control Study_10.1021acs.jproteome.5b00977.pdf | 4.25 MB | Adobe PDF |
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