Please use this identifier to cite or link to this item
|title: ||Wettability gradient-induced alignment of peptide nanotubes as templates for biosensing applications|
|authors: ||Almohammed, Sawsan|
Oladapo, Sarah O.
Kholkin, Andrei L.
Rice, James H.
Rodriguez, Brian J.
|issue date: ||2016|
|publisher: ||Royal Society of Chemistry|
|abstract: ||Self-assembled diphenylalanine (FF) peptide nanotubes (PNTs) have attracted significant attention due to
their well-ordered supramolecular structure and wide range of functional capabilities that may enable
potential nanobiotechnology applications. However, self-assembled PNTs are generally inhomogeneous
at the macroscale, which has limited their potential use. Reproducibly controlling the assembly and
alignment of PNTs is therefore critical to enable the widespread use of PNTs, e.g., in sensing
applications. In this study, a surface patterning technique based on UV/ozone exposure through a mask
is used to align PNTs. Exposed regions become hydrophilic, leading to directed spreading of the FF
solution and alignment of the PNTs that improves as the difference in wettability between adjacent
regions increases. Alignment was further found to depend on the concentration- and temperaturedependent
diameter of the PNTs formed and the size of the hydrophilic area. Finally, aligned PNTs
decorated with silver nanoparticles are used to sense an analyte molecule using surface enhanced
|publisher version/DOI: ||http://doi.org/10.1039/c6ra05732b|
|source: ||Rsc Advances|
|appears in collections||CICECO - Artigos|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.