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|title: ||Ecotoxicological effects of salicylic acid in the freshwater fish Salmo trutta fario: antioxidant mechanisms and histological alterations|
|authors: ||Nunes, B.|
Campos, J. C.
Braga, M. R.
Ramos, A. S.
Antunes, S. C.
Correia, A. T.
|keywords: ||Pharmaceutical drugs|
|issue date: ||2015|
|abstract: ||The presence of pharmaceutical drugs in aquatic
ecosystems has been widely reported during the past years.
Salicylic acid (SA) is mainly used in human medicine as an
analgesic and antipyretic drug, being also active in preventing
platelet aggregation. To study the ecotoxicological effects
potentially elicited by SA in freshwater fish, brown trout
individuals (Salmo trutta fario) were chronically exposed
(28 days) to this drug, in order to evaluate the enzymatic and
histological effects, in both gills and liver. A qualitative and
semi-qualitative evaluation of the gills and liver was performed,
and also a quantitative evaluation of various lamellar
structures. Oxidative stress was quantified trough the determination
of glutathione S-transferases (GSTs), glutathione
reductase (GRed), total and selenium-dependent glutathione
peroxidase (GPx) and Catalase (Cat) activities. Lipid
peroxidative damage was also assessed by the quantification
of thiobarbituric acid reactive substances (TBARS) in the
liver. The here-obtained data showed the occurrence of oxidative
stress, reflected by an increased activity of GPx and
GRed in the liver; additionally, it was possible to observe nonspecific
histological changes in gills. The global significance
of the entire set of results is discussed, giving emphasis to the
ecological relevance of the responses.|
|publisher version/DOI: ||http://dx.doi.org/10.1007/s11356-014-3337-2|
|source: ||Environmental science and pollution research|
|appears in collections||CESAM - Artigos|
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