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 Optimal control of a tuberculosis model with state and control delays
Please use this identifier to cite or link to this item http://hdl.handle.net/10773/16643

title: Optimal control of a tuberculosis model with state and control delays
authors: Silva, Cristiana J.
Maurer, Helmut
Torres, Delfim F.M.
keywords: Optimal control
Stability
Time delays
Tuberculosis
issue date: Feb-2017
publisher: American Institute of Mathematical Sciences
abstract: We introduce delays in a tuberculosis (TB) model, representing the time delay on the diagnosis and commencement of treatment of individuals with active TB infection. The stability of the disease free and endemic equilibriums is investigated for any time delay. Corresponding optimal control problems, with time delays in both state and control variables, are formulated and studied. Although it is well-known that there is a delay between two to eight weeks between TB infection and reaction of body's immune system to tuberculin, delays for the active infected to be detected and treated, and delays on the treatment of persistent latent individuals due to clinical and patient reasons, which clearly justifies the introduction of time delays on state and control measures, our work seems to be the first to consider such time-delays for TB and apply time-delay optimal control to carry out the optimality analysis. © 2017, Arizona State University. All rights reserved.
URI: http://hdl.handle.net/10773/16643
ISSN: 1547-1063
publisher version/DOI: http://dx.doi.org/10.3934/mbe.2017021
source: Mathematical Biosciences and Engineering
appears in collectionsCIDMA - Artigos

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